Our new Clear+ tissue clearing approach is the one system that delipidates samples without having change in morphology and with minimum effect on structural integrity.

Megatome is often a vibrating microtome meant to section a broad selection of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With large blade vibrating frequency and minimized blade deflection, Megatome allows substantial-throughput tissue sectioning with uniform area profile, and minimal tissue harm and information loss.

Antibodies may take weeks to diffuse through only a few millimeters of tissue, with a steep labeling gradient from surface area to Main.

Megatome is suitable for accuracy: the blade vibrates at a greater frequency and larger amplitude assortment than other microtomes, and includes a special deflection Manage mechanism.

SE works by using a rotational electrical discipline to disperse hugely electromobile molecules (which include antibodies or surfactant micelles) in the course of a porous sample devoid of detrimental electrically charged structures throughout the tissue. This allows two-4 day clearing of intact organs,

Our preformulated EasyIndex Option raises and homogenize the refractive index of delipidated tissue samples, rendering them completely transparent. This enables mild penetration into the sample and assures the acquisition of higher-resolution, in-emphasis picture information.

Megatome is a novel microtome that allows for top-precision sectioning of a wide array of tissue samples – from organoids, to arrays of animal organs, to intact human brain hemispheres – with small tissue injury and knowledge reduction.

eFLASH is really a swift tissue labeling approach which allows for uniform complete-organ staining in 20 rounds of labeling.

Totally delipidate full mouse brains or comparably sized samples in only one day with SmartBatch+, or in a single 7 days with our passive megatomi.com clearing kit.

--icon: Specify an icon for use for your docset. Really should be a 32x32 PNG, but this Instrument isn't going to verify the file's material. No icon are going to be employed if This is certainly omitted.

This may develop a docset named Sample in The existing directory. Docset development is usually personalized with optional arguments:

Defend avoids the variability of hydrogel embedding and the data loss from PFA preservation, safeguarding specimens for various rounds of processing.

--displayName: Will set the name as shown in Dash. This is certainly handy should you develop a docset with identify SampleProject but Display screen name Sample Undertaking as a substitute. This location will default to the value of --title if omitted.

Our novel SHIELD tissue preservation method kinds intramolecular bonds working with polyfunctional, adaptable epoxides to stabilize tissue architecture and safeguard the sample’s endogenous fluorescence, protein antigenicity and nucleic acids.